INTRAVENOUS AND SUBCUTANEOUS TOXICITY AND ABSORPTION KINETICS IN MICE AND DOGS OF THE ANTILEISHMANIAL TRITERPENE SAPONIN PX-6518

The intravenous (IV) and subcutaneous (SC) toxicity and absorption kinetics of the antileishmanial triterpene saponin PX-6518 and its active constituents maesabalide-III and -IV were studied in mice and dogs.A high-dose wash-out study of PX-6518 at 20 mg/kg SC for NPG-Surcharge 5 days and a single low-dose wash-out study at 1, 2.5 or 5 mg/kg SC and